Bone Resorption Assessment-Genova Kit (DO NOT USE)

Note: This is a home collection test kit that will be mailed to you.

Fasting Required: No

Specimen: Urine

Lab: Genova Diagnostics

Results: 10-14 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions: Abnormal kidney function or use of diuretics may influence test results.
This test should not be performed on individuals with kidney disorders.
If any of the following factors apply to you, it is advisable to delay testing. Please consult your healthcare provider:
• Urinary tract infection
• Pregnancy or lactation
• Bone fracture: Levels may remain elevated for up to one year
• Spinal cord injury; severe burns
• Use of medicines or supplements such as cephalosporins, trimethoprim (e.g. Bactrim®TM), doxycycline, sulfasalazine, and Human Growth Hormone

Description: The Bone Resorption Assessment is a simple urinary test that provides an accurate assessment of the rate of bone turnover in an individual. The Bone Resorption Assessment allows the practitioner to identify those more likely to develop osteoporosis, to intervene before significant loss has occurred, and to monitor the efficacy of treatment regimens. It examines pyridinium crosslinks and deoxypyridinoline and is useful in identifying current rate of bone loss, lytic bone disease, and efficacy of bone support therapies.

Pyridinium crosslinks are stabilizers of collagen molecules. Bone collagen contains bothpyridinoline (PYD), which is reflective of collagen loss of all types, and its component deoxypyridinoline (DPD), which specifically reflects bone collagen. Presence in the urine of higher than normal amounts of PYD and DPD indicate a rapid rate of bone loss.
Crosslink excretion is greatly increased in patients with osteoporosis, as well as in a number of other conditions. These include Paget's disease, primaryhyperparathyroidism, and osteomalacia. Measurement of PYD crosslinks has also proven useful in arthritic diseases, connective tissue disorders, cancer metastasis, and alcoholic bone disease.

Analytes Tested:
Pyridinium Crosslinks