Lipid Peroxides (109)-BioHealth Kit

Note: This is a home collection test kit that will be mailed to you.

Fasting Required: No

Specimen: Urine, 2 samples from first morning's urine

Results: 10-14 Business Days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Specimen Collection: The day before collection: It is important that you have a protein-rich meal the evening before collection. At dinner time (after 4 pm), eat at least 6 ounces of meat. Vegetarians can substitute with at least 8 ounces of legumes, nuts, or seed-based products, including tofu and tempeh. Unless instructed otherwise by your health care professional, do not consume: Alcohol, protein powders or drinks, Iodine supplements or amino acid supplements, probiotics, digestive enzymes or Hydrochloric acid.

Description Lipid peroxidation is a well-established mechanism of cellular injury and is used as an indicator of oxidative stress, also known as “free radical damage.”

The elevation of lipid peroxides serves as an early warning of the potential long-term effects of oxidative stress. The outcome of long-term oxidative stress is chronic degenerative disease, an example being the peroxidation of low-density lipoproteins contributing to atherosclerosis. Oxidative stress can result from exposure to toxins or pathogens, inappropriate lifestyle – such as over-exercising or smoking – or byproducts of normal metabolism.

The degree of lipid peroxide elevation can be used as a guideline for lifestyle modification and further testing. It can also help to determine antioxidant supplementation for helping to boost resistance to free radical damage. A slight elevation would require a less aggressive approach using minimal/maintenance levels of antioxidants. Moderate to extreme elevations would necessitate a more aggressive antioxidant regime, particularly in the short term, until follow-up testing indicates a return to normal levels.

Though not necessarily present in most patients, symptoms of elevated lipid peroxides include: Fatigue, memory loss, brain fog, muscle and/or joint pain, wrinkles, impaired eyesight, headaches, and susceptibility to infections.

Elevated lipid peroxide readings prompt further lab testing as well as lifestyle modifications and nutritional supplementation. Antioxidant intake, in the form of foods and nutritional supplements, is often indicated, with the most common nutrients being: Coenzyme Q10, alpha lipoic acid, vitamin E, B12, grapeseed extract, and vitamin D.

Lipid peroxides, derived from polyunsaturated fatty acids, are unstable and decompose to form a complex series of compounds, which include reactive carbonyl compounds, such as malondialdehyde (MDA). MDA can be quantified through a controlled reaction with thiobarbituric acid, generating thiobarbituric acid reactive substances (TBARS). The TBARS assay is a well-recognized, established method for quantifying these lipid peroxides, especially on urine in which there are few significant interfering substances. Steps are employed in the assay procedure to further reduce interference, rendering it a reliable measure of lipid peroxidation.

The reference range for BioHealth’s lipid peroxides assay is <7.0 umol/g measured in units of creatinine concentration.