Secretory IgA (310)-BioHealth Kit (DO NOT USE)

Note: This is a home collection test kit that will be mailed to you.

Fasting Required: No

Specimen: Saliva, Single vial collection over the course of one day

Results: 10-14 Business Days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Collection Instructions: Place the ice gel pack flat in your freezer and freeze for at least 36 hours. On day of collections: Do not drink caffeine or alcohol or smoke, unless otherwise instructed by your clinician. One hour before collection: Do not brush your teeth, use dental floss or use mouthwash. Do not eat or drink anything except water. Unless instructed otherwise by your clinician, avoid taking any hormones on the day of collection. If you are unsure about this, contact your clinician.

Description Mucosal surfaces are the first lines of defense against invasion and colonization by pathogenic microorganisms. The principal molecule of mucosal immune responses is Secretory IgA (sIgA), which is produced by activated B-cells. Upon activation, B-cells in the mucosa form immune complexes with the pathogens and antigens encountered, thereby preventing antigen attachment to the intestinal wall, which may result in antigen penetration of the intestinal lining.

IgA is the only immunoglobulin isotype that can be selectively passed across mucosal walls to reach the lumens of organs lined with mucosal cells. An imbalance of protective SIgA can result in a compromised mucosal immunity and eventual gastrointestinal, immunological and neurological disorders.