CICA: Genetic Only-Cell Science Systems Kit

Note: This is a test kit that will be mailed to you. It can be performed using a swab or a blood draw. Unless we are told otherwise, the swabs will be sent to you. It is your responsibility to arrange for the blood draw for your kit should you choose the blood draw.

Specimen: Swab or blood by request only

Fasting Required: No

Results: 10-12 Business days once the lab receives the specimen
Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Patient Recommendations: Gluten consumption prior to testing would not impact the results. Continue with current eating pattern. No change in gluten consumption is necessary.

Reported: HLA typing for celiac disease: HLA-DQ2.5 and HLA-DQ8; Genetic Markers for Crohn's: ATG16L1 and NOD2.

Description: The Celiac, IBS, and Crohn’s Array (CICA) evaluates your genetic risk for celiac disease, serum markers associated with active celiac disease process, and genetic serum markers associated with Crohn’s disease.

The CICA is a comprehensive test array that analyzes genetic predisposition, detects specific antibodies, and measures potentially inflammatory cellular reactions all through one simple blood draw.

Celiac disease risk analysis is determined based on the presence or absence of the HLA-DQ genotypes. Both the DQ8 and DQ2.5 genotypes are tested in this array, with the DQ2.5 genotypes representing a much greater risk of celiac disease. Four specific serum antibodies (DGP IgG/IgA and tTG IgG/IgA) are tested due to their high sensitivity and specificity for active celiac disease. The higher the antibody levels, the more likely untreated celiac disease is present. Genetic markers, mutations in the ATG16L1 and NOD2 genes, associated with the Crohn’s disease are tested along with serologic markers for complete assessment. Anti-Saccharomyces Cerevisiae Antibody (ASCA; IgG/IgA) are immune proteins that are frequently present in people who have Crohn’s disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including an association with active Crohn’s disease.

Optionally, it can be combined with the Alcat Test at a discounted rate to evaluate innate immune cell responses to as many as 400 other foods (including gluten, gliadin, casein and whey) and substances for the most comprehensive assessment.