Zonulin Family Protein (Properdin), serum-Doctor's Data Kit

Note: This is a test kit that will be mailed to you. It requires a blood draw. It is your responsibility to arrange the blood draw for your kit and payment of your specimen collection.



Fasting Required: No

Specimen: Blood

Results: 5-7 Business Days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Patient Instructions: Fasting is not required for these tests. It is generally recommended to refrain from taking non-essential medications and dietary supplements for 72 hours prior to the specimen collection unless otherwise instructed by your physician. Never discontinue prescription medications without first consulting your physician.

Description: In recent years, scientists have identified zonulin as a key biomarker for intestinal permeability, which has been associated with celiac disease, non-celiac gluten sensitivity (NCGS), and other GI and systemic conditions.

In a healthy GI tract, the tight junctions between cells prevent unregulated influx of luminal contents. However, certain situations, such as the presence of gluten for people with celiac disease or NCGS, can lead to high levels of zonulin in the GI tract. This can induce the breakdown of the tight junctions, leading to intestinal permeability and allowing zonulin to enter the bloodstream.

As a result, circulating zonulin is a clinically useful marker of intestinal permeability. What's more, zonulin is the only regulator of intestinal permeability known to be reversible, which makes it valuable in monitoring therapeutic interventions as well.

Several autoimmune, inflammatory and neoplastic diseases have been associated with elevated levels of zonulin or evidence of increased intestinal permeability, which can be identified by our Serum Zonulin test.