Comprehensive Plus Profile-Labrix Kit

Note: This is a home collection test kit that will be mailed to you.


Fasting Required: No.

Specimen: 4 Saliva Samples

Results: 3 - 5 business days.

Tests Included: Estrone (E1), Estradiol (E2), Estriol (E3), Progesterone (Pg), Testosterone (T), DHEA (D), Cortisol x 4

Special Instructions: WOMEN AND MEN ON HORMONES (estrogen, progesterone, testosterone, melatonin and DHEA):
• Topical Hormones (cream) DO NOT APPLY ANY TOPICAL HORMONES THROUGHOUT THE ENTIRE DAY OF SALIVA COLLECTION. This will contaminate your sample and compromise your test results. Your last dose prior to saliva collection should be applied within a window of 12 – 24 hours before collecting your first saliva sample.

• Sublingual Hormones or Troches (dissolved under tongue) DO NOT USE ANY SUBLINGUAL HORMONES THROUGHOUT THE ENTIRE DAY OF SALIVA COLLECTION. This will contaminate your sample and compromise your test results. Your last dose prior to saliva collection should be taken within a window of 24 – 36 hours before collecting your first saliva sample, followed by two 8 oz. glasses of water.

• Oral Hormones (pills) Should be used as prescribed on the day of collection.

• Injections, Subcutaneous Pellets and Transdermal Patches it is recommended to collect mid cycle of the dosage interval.

CORTISOL/GLUCOCORTICOID SUPPLEMENTATION: CONSULT WITH YOUR PROVIDER for instruction if you are taking a cortisol supplement for adrenal support (or any other glucocorticoid for medical reasons). Note: certain medications, including hydrocortisone creams and asthma inhalers, contain cortisol. To evaluate your natural cortisol production, it is recommended to stop using cortisol-containing products 5 days prior to sample collection. Consult with your provider prior to stopping cortisol-containing medication(s).

WOMEN WITH MENSTRUAL CYCLES: Collect saliva during one day of the mid-luteal phase (day 19-23 of a 28-day cycle)* counting the first day of your period as day 1. If your cycle is irregular, contact your provider for direction on when to collect your samples POST-MENOPAUSAL WOMEN OR WOMEN WHO HAVE HAD A HYSTERECTOMY: Collect saliva any day of the month. (If using hormones, please read and follow guidelines above)

WOMEN WITH IUD: Does not change usual testing guidelines.

MEN NOT ON HORMONES: Collect saliva on any day. (If using hormones, please read and follow guidelines above

Description: The Comprehensive Plus Panel expands on the Comprehensive Hormone Panel and includes estrone (E1) and estriol (E3) plus the Estrogen Quotient. The Estrogen Quotient (EQ) is a simple ratio of the cancer protective E3 to the proliferative estrogens E1 and E2. The EQ provides an assessment of breast cancer risk, with a lower number (<1.0) indicating increased risk, and a higher number (>1.0) signifying a lower risk. For maximum protection, an optimal EQ is >1.5. Because the research on the Estrogen Quotient and the protective properties of estriol has not been done with men, this panel is currently recommended for women only. This panel should be considered for patients who have:

Increased risk of developing breast cancer
History of breast cancer or other hormonally sensitive cancers
Personal or family history of autoimmune disease
PCOS

Estrogens: There are three forms made by the body: estrone, estradiol and estriol. The form used in past hormone replacement therapies is estradiol, often in the form of concentrated pregnant mare’s urine (premarin). It is a proliferative (causes growth) hormone that grows the lining of the uterus. It is also a known cancer-causing hormone: breast and endometrial (uterine) in women and prostate gland in men. It will treat menopausal symptoms like hot flashes, insomnia and memory-loss. With the bio-identical formulas estriol is matched with estradiol (biest) to provide protective effects and additional estrogenic benefits. The other major protector in keeping estradiol from running amok is progesterone. Estrone and estriol are also useful hormones to test.

Progesterone: Called the anti-estrogen because it balances estradiol’s proliferative effects. It is considered preventive for breast and prostate cancers as well as osteoporosis. In addition, too little progesterone promotes depression, irritability, increased inflammation, irregular menses, breast tenderness, urinary frequency and prostate gland enlargement (BPH).

Testosterone: An anabolic hormone (builds tissue) that is essential for men and women. The proper level of testosterone is necessary for bone health, muscle strength, stamina, sex drive and performance, heart function and mental focus.

DHEA: An important adrenal gland hormone, which is essential for energy production and blood sugar balance. DHEA is a precursor to other hormones, mainly testosterone.

Cortisol: Your waking day hormone (highest in the morning and lowest at night). It is necessary for energy production, blood sugar metabolism, anti-inflammatory effects and stress response.

Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.