Abacavir - Hypersensitivity (HLA-B*57:01)-Kashi Clinical Lab Kit

Note: This is a test kit that will be mailed to you for an at home collection



Fasting Required: No

Lab: Kashi Clinical Laboratories, Inc.

Specimen: Buccal Swab

Results: 5-7 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Description: Abacavir sulfate is a nucleoside reverse transcriptase inhibitor that is prescribed in combination with other antiviral drugs to treat HIV infection. In some patients, its use can cause abacavir sulfate hypersensitivity reaction (ABC HSR), a serious and sometimes fatal condition that appears within the first six weeks of treatment and is characterized by symptoms that appear suddenly and worsen with subsequent doses of abacavir. These symptoms include fatigue, rash, fever, nausea, vomiting, diarrhea, and respiratory symptoms, with fatal reactions often being associated with at least two of the above. Symptoms also generally improve within 48 to 72 hours of discontinuing abacavir treatment.Graves’ Disease is an autoimmune disease of the thyroid gland. It is characterized by hyperthyroidism associated with goiter, heart palpitations, bulging eyes, sweating, heat intolerance, tremor, anxiety and weight loss. The immunological response in Graves’ Disease comprises diffuse lymphocyte infiltration into the thyroid gland with thyroid stimulating immunoglobulin (TSI) autoantibody production. The hyperthyroidism is caused by activation of the thyroid stimulating hormone receptor (TSHR) by binding of autoantibodies.