Glutamic Acid Decarboxylase (GAD) AutoAb
10-14 Business Days
Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. This is one of the most commonly detected autoantibodies in newly diagnosed type 1 diabetics (about 70-80%). Generally used to confirm type 1 diabetes and ruling out type 2 diabetes.
GAD-65 antibodies are detected in 20% of diabetic twins who remain disease-free for long periods of time and in 8% of healthy individuals.
Glutamic Acid Decarboxylase (GAD-65) Antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess risk for development of IDDM, to predict onset of IDDM, and risk of development of related endocrine disorders, e.g., thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells, and by circulating autoantibodies against a variety of islet cell antigens, including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin autoantibody (IAA).
Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.