GI Effects® Comprehensive Profile - Stool (One Day Collection)-Genova Kit

Note: This is a home collection test kit that will be mailed to you. NOT to be used for children under the age of 2. This is a one day collection kit.


Fasting Required: No

Specimen: Stool

Results: 14-21 Business Days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions: 2 - 4 weeks prior to testing: Consult with your physician before stopping any medications. Certain medications and/or supplements may impact test results.
Discontinue antibiotics, antiparasitics, antifungals, probiotic supplements (acidophilus, etc)
Discontinue proton pump inhibitors (PPIs) and bismuth 14 days prior if adding on the H. pylori test.
2 days before the test: Discontinue aspirin and other NSAIDs (i.e. ibuprofen), rectal suppositories, enemas, activated charcoal, bismuth, betaine HCL, digestive enzymes, antacids, laxatives, mineral oil, castor oil and/or bentonite clay.

Description: The GI Effects® Comprehensive Stool Profile is an advanced stool test that provides immediate, actionable clinical information for the management of gastrointestinal health. Utilizing cutting-edge technologies and biomarkers, this test offers valuable insight into digestive function, intestinal inflammation, and the intestinal microbiome.

The biomarkers from the GI Effects Comprehensive Profile are reported using the DIG framework, providing key clinical information for three main gastrointestinal functional areas:

Digestion/Absorption: Pancreatic Elastase-1 is a marker of exocrine pancreatic function. Products of Protein Breakdown are markers of undigested protein reaching the colon. Fecal Fat is a marker of fat breakdown and absorption.

Inflammation/Immunology: Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response. Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.

Gut Microbiome: Metabolic indicators, including short-chain fatty acids and beta-glucuronidase, demonstrate specific and vital metabolic functions performed by the microbiota. Commensal Bacteria demonstrate the composition and relative abundance of gut organisms. More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques. GI Effects assesses a set of 24 genera/species that map to 7 major phyla. Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms. Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic organisms that have been cultured. The report includes effective prescriptive and natural agents. Parasitology GI Effects provides microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites. 6 Polymerase chain reaction (PCR) targets detect common protozoan parasites including Blastocystis spp. with reflex subtyping 1-9, Cryptosporidium spp., Cyclospora cayetanensis, Dientamoeba fragilis, Entamoeba histolytica, and Giardia. PCR for organisms is emerging as a highly sensitive method for infectious organism detection. Selection of a one-day or three-day sample collection is based on clinician's clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.

Analytes Reported:
Acetate %
Akkermansia muciniphila
Anaerotruncus colihominis
Bacteriology
Bacteroides vulgatus
Bacteroides-Prevotella group
Barnesiella spp.
Beta- glucuronidase
Bifidobacterium longum
Bifidobacterium spp.
Butyrivibrio crossotus
Calprotectin
Cholesterol
Clostridium spp.
Collinsella aerofaciens
Color
Consistency
Coprococcus eutactus
Desulfovibrio piger
Eosinophil Protein X (EPX)
Escherichia coli
Faecalibacterium prausnitzii
Fecal Fat (Total)
Fecal Occult Blood
Fecal sIgA
Firmicutes/Bacteroidetes (F/B Ratio)
Fusobacterium spp.
Lactobacillus spp.
Long Chain Fatty Acids
Methanobrevibacter smithii
Mic Sensitivities, Yeast or Bacteria
Microscopic Exam Results
Mycology (Yeast/Fungi)
Odoribacter spp.
Oxalobacter formigenes
Pancreatic Elastase 1
Parasitology
Parasitology EIA Tests
Phospholipids
Prevotella spp.
Products of Protein Breakdown (Total) (Valerate+Isobutyrate+Isovalerate)
Propionate %.
Pseudoflavonifractor spp.
Roseburia spp.
Ruminococcus spp.
SCFA (Total) (Acetate, n-Butyrate, Propionate)
Triglycerides
Veillonella spp.
n-Butyrate %
n-Butyrate Concentration

Additional Biomarkers Available for add-on at additional cost:
Campylobacter
Clostridium difficile
Escherichia coli
Fecal Lactoferrin
Helicobacter pylori
Macro Exam for Worms
Zonulin Family Peptide
KOH Preparation for Yeast