GI Effects® Microbial Ecology Profile (One Day Collection)-Genova Kit

Note: This is a home collection test kit that will be mailed to you. NOT to be used for children under the age of 2.

Fasting Required: No

Specimen: Stool - 3 Day collection

Results: 14-21 Business Days Due to vendor supply issues test results are taking the full 21 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions: Ship to lab Monday-Thursday only. Specimen MUST be shipped within 48 hours of collection.
2 - 4 weeks prior to testing: Consult with your physician before stopping any medications. Certain medications and/or supplements may impact test results.
Discontinue antibiotics, antiparasitics, antifungals, probiotic supplements (acidophilus, etc)
Discontinue proton pump inhibitors (PPIs) and bismuth 14 days prior if adding on the H. pylori test.
2 days before the test: Discontinue aspirin and other NSAIDs (i.e. ibuprofen), rectal suppositories, enemas, activated charcoal, bismuth, betaine HCL, digestive enzymes, antacids, laxatives, mineral oil, castor oil and/or bentonite clay.

Description: The GI Effects Microbial Ecology Profile is the most comprehensive stool test that assesses the diverse gut microbiome. Results provide immediate, actionable clinical information for the management of detectable parasites, bacteria, and yeast, as well as providing valuable assessment of gut microbiota via 24 Commensal Bacteria targets.

The GI Effects Microbial Ecology Profile is part of the larger GI Effects Comprehensive Stool Profile, which also provides information about digestion, inflammation, and bacterial metabolism markers. A larger fecal biomarker panel such as the GI Effects Comprehensive Stool Profile offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea could stem from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism.

Patients with a clinical history suggestive of a gastrointestinal infection or dysbiosis can be evaluated with the GI Effects Microbial Ecology Profile. Symptoms such as gas, bloating, abdominal pain, diarrhea, and constipation may be a result of a microbial imbalance or infection. This profile can also be used to monitor treatment efficacy to eradicate an organism or to monitor changes to the microbiota.

Gut microbes are codependent with one another and with their human host, and the health of one affects the other. A sizeable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract. The microbiome's diverse metabolic activities ultimately impact the human host, and the human hosts activities ultimately affect the microbiome's health.

The GI Effects Microbial Ecology Profile biomarkers include:

Commensal Bacteria demonstrate the gut microbiomes composition and relative abundance. More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques. Polymerase Chain Reaction (PCR) methodology identifies bacterial populations and is considered the standard for anaerobic bacteria assessment. GI Effects assesses a set of 24 genera/species that map to 7 major phyla.

Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.

Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic cultured organisms. The report includes effective prescriptive and natural agents.

Parasitology. GI Effects provides microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
Enzyme immunoassay (EIA), widely recognized for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia. 6 Polymerase chain reaction (PCR) targets detect common protozoan parasites including Blastocystis spp. with reflex subtyping 1-9, Cryptosporidium spp., Cyclospora cayetanensis, Dientamoeba fragilis, Entamoeba histolytica, and Giardia. PCR for organisms is emerging as a highly sensitive method for infectious organism detection.

Selection of a one-day or three-day sample collection is based on clinician's clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.

Analytes Reported:
Akkermansia muciniphila
Anaerotruncus colihominis
Bacteroides vulgatus
Bacteroides-Prevotella group
Barnesiella spp.
Bifidobacterium longum
Bifidobacterium spp.
Butyrivibrio crossotus
Clostridium spp.
Collinsella aerofaciens
Coprococcus eutactus
Desulfovibrio piger
Escherichia coli
Faecalibacterium prausnitzii
Fecal Occult Blood
Firmicutes/Bacteroidetes (F/B Ratio)
Fusobacterium spp.
Lactobacillus spp.
Methanobrevibacter smithii
Mic Sensitivities, Yeast or Bacteria
Microscopic Exam Results
Mycology (Yeast/Fungi)
Odoribacter spp.
Oxalobacter formigenes
Parasitology EIA Tests
Prevotella spp.
Pseudoflavonifractor spp.
Roseburia spp.
Ruminococcus spp.
Veillonella spp.

Additional Biomarkers Available for add-on at additional cost:
Clostridium difficile
Escherichia coli
Helicobacter pylori
Macro Exam for Worms
KOH Preparation for Yeast
Zonulin Family Peptide
Fecal Lactoferrin