Metabolomix+ - Genova Kit

Note: This is a home collection test kit that will be mailed to you.

Fasting Required: Yes 8 Hours

Specimen: Urine

Lab: Genova Diagnostics

Results: 14 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions:
• Testing is not available for patients less than 2 years old
• Female patients should not collect during menstrual period

2 Days before the test
• Discontinue all of the following (unless instructed otherwise by your physician):
» Supplements containing creatine, vitamin C or any mineral elements measured on this test
» Other substances that may influence urinary element excretion of elements
» Seafood (unless asked to continue by your healthcare provider)
» Continue with the above food restrictions until your sample is completely collected

24 hrs before the test:
• Eat usual diet, but avoid over-consuming any single food or extreme diet
• Fluid intakes should be limited to eight (8) 8-ounce glasses of fluid over a 24 hour period

Description: The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to the precise needs of their patients.

Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.

Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.1-5 Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.

Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error.* In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors.

Organic Acids
Malabsorption and Dysbiosis
Cellular Energy and Mitochondrial Metabolites
Neurotransmitter Metabolites
Vitamin Markers
Toxin and Detoxification Markers
Tyrosine Metabolism

Amino Acids
Nutritionally Essential Amino Acids
Nonessential Protein Amino Acids
Intermediary Metabolites
Dietary Peptide Related Markers

Oxidative Stress Markers

Essential and Metabolic Fatty Acids - Bloodspot (if selected as add-on profile)
Omega 3 Fatty Acids
Omega 6 Fatty Acids
Omega 9 Fatty Acids
Saturated Fatty Acids
Monounsaturated Fatty Acids
Delta-6 Desaturase Activity
Cardiovascular Risk

Nutrient and Toxic Elements (if selected as add-on profile)

Additional Biomarkers Available for add-on at additional cost:
Essential and Metabolic Fatty Acids - Bloodspot
Toxic Elements Clearance
Comprehensive Urine Elements
MTHFR (C677T & A1298C)
COMT (V158M)

Analytes reported
Gallium (Add-on)
Gamma-Linolenic (Add-on)
Gamma-aminobutyric acid
Glutamic acid
Glutaric Acid
Gondoic (Add-on)
Homogentisic Acid
Homovanillic Acid
Indoleacetic Acid
Iron (Add-on)
Isocitric Acid
Kynurenic Acid
Lactic Acid
Lead (Add-on)
Lignoceric (Add-on)
Linoleic (Add-on)
Lipid Peroxides
Lithium (Add-on)
MTHFR (C677T and A1298C) (Add-on)
Magnesium (Add-on)
Malic Acid
Manganese (Add-on)
Margaric (Add-on)
Mercury (Add-on)
Methylmalonic Acid
Molybdenum (Add-on)
Nervonic (Add-on)
Nickel (Add-on)
Niobium (Add-on)
Oleic (Add-on)
Orotic Acid
Palmitic (Add-on)
Palmitoleic (Add-on)
Pentadecanoic (Add-on)
Phenylacetic Acid
Platinum (Add-on)
Potassium (Add-on)
Pyroglutamic Acid
Pyruvic Acid
Rubidium (Add-on)
Selenium (Add-on)
Stearic (Add-on)
Strontium (Add-on)
Suberic Acid
Succinic Acid
Sulfur (Add-on)
TNF-a (Add-on)
Thallium (Add-on)
Thorium (Add-on)
Tin (Add-on)
Tricosanoic (Add-on)
Tungsten (Add-on)
Uranium (Add-on)
Vaccenic (Add-on)
Vanadium (Add-on)
Vanilmandelic Acid
Zinc (Add-on)
a-Keto-b-Methylvaleric Acid
a-Ketoadipic Acid
a-Ketoglutaric Acid
a-Ketoisocaproic Acid
a-Ketoisovaleric Acid
alpha-Linolenic (Add-on)
b-OH-Butyric Acid
b-OH-b-Methylglutaric Acid